BILN2061, telaprevir and boceprevir treatment of chronic hepatitis C clinical comparison
Easy HCV infection leads to chronic hepatitis, cirrhosis and liver cancer and other related diseases, high mortality. HCV is translated in vivo by host signal peptide and non-structural proteins (non-structural protein, NS) 3 viral proteolytic maturation. In addition, NS3 also directly damage host cells and inhibit their responses to interferon, therefore HCV NS3 study has important clinical significance. Based on the three kinds of NS3/4A protease inhibitors (BILN2061, telaprevir and boceprevir) pharmacological effects, pharmacokinetics and metabolism, safety and clinical studies were analyzed, summarized its role characteristics and clinical efficacy. Meanwhile, boceprevir and telaprevi (rVX-950) were combined with pegylated interferon and ribavirin to evaluate the efficacy for the treatment of chronic hepatitis C clinicians to provide guidance.
BILN2061, telaprevir and boceprevir treatment of chronic hepatitis C clinical comparison
ReplyDeleteEasy HCV infection leads to chronic hepatitis, cirrhosis and liver cancer and other related diseases, high mortality. HCV is translated in vivo by host signal peptide and non-structural proteins (non-structural protein, NS) 3 viral proteolytic maturation. In addition, NS3 also directly damage host cells and inhibit their responses to interferon, therefore HCV NS3 study has important clinical significance. Based on the three kinds of NS3/4A protease inhibitors (BILN2061, telaprevir and boceprevir) pharmacological effects, pharmacokinetics and metabolism, safety and clinical studies were analyzed, summarized its role characteristics and clinical efficacy. Meanwhile, boceprevir and telaprevi (rVX-950) were combined with pegylated interferon and ribavirin to evaluate the efficacy for the treatment of chronic hepatitis C clinicians to provide guidance.
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