JBC: confirmed two kinds of anti-cancer drugs that inhibit influenza virus infection
September 8, 2012 - University of Helsinki, Finland, from the Finnish Institute for Molecular Medicine , a medical systems virology team collaboration with other partners to develop a new cell-based screening method, and this method can be used to identify anti- influenza virus drugs. Researchers have identified two new anti-influenza virus activity of the compound obatoclax and gemcitabine (gemcitabine), a previously known and confirmed the efficacy of drugs saliphenylhalamide . This study has been published in the Journal of Biological Chemistry journals .
Influenza virus to cause significant morbidity and mortality people . For the treatment of these viral infections , various targeting viral drugs have been developed . However , currently available drugs are targeting viral proteins , but because influenza viruses mutate rapidly develop resistance to them . For this reason , should be targeted next host antiviral function . The results of this study lay the foundation for developing the next generation of antiviral drugs . Furthermore, these drugs have been identified chemical tools can be used to enable the study of virus - host interactions molecular mechanism.
Corresponding author Denis Kainov papers , says the study 's interesting is that the drug obatoclax, saliphenylhalamide and gemcitabine even mediated cell death in higher than lower concentrations needed , they can exhibit anti-viral effect . However, these drugs can be used in clinical testing and influenza virus infection before , further research is needed.
JBC: confirmed two kinds of anti-cancer drugs that inhibit influenza virus infection
ReplyDeleteSeptember 8, 2012 - University of Helsinki, Finland, from the Finnish Institute for Molecular Medicine , a medical systems virology team collaboration with other partners to develop a new cell-based screening method, and this method can be used to identify anti- influenza virus drugs. Researchers have identified two new anti-influenza virus activity of the compound obatoclax and gemcitabine (gemcitabine), a previously known and confirmed the efficacy of drugs saliphenylhalamide . This study has been published in the Journal of Biological Chemistry journals .
Influenza virus to cause significant morbidity and mortality people . For the treatment of these viral infections , various targeting viral drugs have been developed . However , currently available drugs are targeting viral proteins , but because influenza viruses mutate rapidly develop resistance to them . For this reason , should be targeted next host antiviral function . The results of this study lay the foundation for developing the next generation of antiviral drugs . Furthermore, these drugs have been identified chemical tools can be used to enable the study of virus - host interactions molecular mechanism.
Corresponding author Denis Kainov papers , says the study 's interesting is that the drug obatoclax, saliphenylhalamide and gemcitabine even mediated cell death in higher than lower concentrations needed , they can exhibit anti-viral effect . However, these drugs can be used in clinical testing and influenza virus infection before , further research is needed.
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