Nietzsche Quote
"To many men life is a failure; a poison-worm gnaweth at their heart. Then let them see to it that their dying is all the more a success .Many never become sweet; they rot even in the summer. It is cowardice that holdeth them fast to their branches."
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FDA-approved treatment for advanced multiple myeloma pomalidomide
ReplyDeletePomalidomide has been approved for use in the treatment received at least two kinds ( including lenalidomide and bortezomib ) still occurs after disease progression , as well as for the treatment of non-response , and in the last 60 days of occurrence of a treatment for multiple myeloma disease progression patients.
"Pomalyst (pomalidomide) is the second lenalidomide and thalidomide allowed after the first three kinds of such immunomodulatory drugs , and is a past year approved for the treatment of multiple myeloma in the first two kinds of drugs ." U.S. Food and Drug Administration (FDA) Center for Drug Evaluation and Research Office of blood and oncology products , Dr. Richard Pazdur said in a statement : " the approval of other drugs ineffective ha un which brings new treatment option ."
Pomalidomide designed as an orphan drug by drug approved by the FDA accelerated approval procedures listed in order to verify the manufacturer to carry out more research efficacy and safety at the same time , so that patients can get earlier this promising new drug .
The drug's safety and efficacy in an included 221 cases of relapsed or refractory multiple myeloma patients in clinical trials has been verified, the group of patients randomized to receive pomalidomide monotherapy or pomalidomide + low-dose dexamethasone . The results show that in the receiving pomalidomide monotherapy patients, 7.4% had an objective response , the response to maintain the median time not yet reached . In an interview with pomalidomide + low-dose dexamethasone -treated patients , 29% had an objective response , the response to maintain the median time over seven months.
Common side effects include neutropenia , fatigue, weakness , anemia , constipation , diarrhea , thrombocytopenia, upper respiratory tract infection , back pain , and fever. Pomalidomide with a boxed warning that the drug can cause blood clots , and because can lead to serious , life-threatening birth defects in pregnant women and disabled .
Only through Pomalyst risk evaluation and mitigation strategy (REMS) program to get pomalidomide. Lenalidomide and thalidomide has a similar REMS.
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