Aurora-B kinase inhibitor AZD1152-HQPA on human osteosarcoma cell line U2-OS cell line
Investigate laser (Aurora)-B kinase inhibitor AZD1152-HQPA on human osteosarcoma cell line U2-OS cells in vitro. Methods with different concentrations of AZD1152-HQPA (0,10,50,100,500 nmol.L-1) in vitro in human osteosarcoma cell line U2-OS24, 48,72 h, using MTT (MTT) test AZD1152-HQPA on human osteosarcoma cell line U2-OS cell line; using Western Blotting detection AZD1152-HQPA effect on the human osteosarcoma cell line U2-OS cells before and after the Aurora-B kinase expression. Results AZD1152-HQPA on human osteosarcoma cell line U2-OS cells significantly inhibited, and the inhibition was time - concentration-dependent manner. 50 nmol.L-1AZD1152-HQPA role 24,48,72 h, human osteosarcoma cell line U2-OS cells Aurora-B kinase with the treatment time is reduced. Conclusion AZD1152-HQ-PA can inhibit U2-OS cells, and inhibition was time - concentration-dependent manner.
Aurora-B kinase inhibitor AZD1152-HQPA on human osteosarcoma cell line U2-OS cell line
ReplyDeleteInvestigate laser (Aurora)-B kinase inhibitor AZD1152-HQPA on human osteosarcoma cell line U2-OS cells in vitro. Methods with different concentrations of AZD1152-HQPA (0,10,50,100,500 nmol.L-1) in vitro in human osteosarcoma cell line U2-OS24, 48,72 h, using MTT (MTT) test AZD1152-HQPA on human osteosarcoma cell line U2-OS cell line; using Western Blotting detection AZD1152-HQPA effect on the human osteosarcoma cell line U2-OS cells before and after the Aurora-B kinase expression. Results AZD1152-HQPA on human osteosarcoma cell line U2-OS cells significantly inhibited, and the inhibition was time - concentration-dependent manner. 50 nmol.L-1AZD1152-HQPA role 24,48,72 h, human osteosarcoma cell line U2-OS cells Aurora-B kinase with the treatment time is reduced. Conclusion AZD1152-HQ-PA can inhibit U2-OS cells, and inhibition was time - concentration-dependent manner.
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