Nutlin-3 against UV-induced human melanocytes protective effects of oxidative DNA damage
Tan City, Jiangsu Province Hospital of Dermatology published a paper aimed at evaluating Nutlin -3 people against UV-induced oxidative DNA damage in melanocytes protective effect. Studies that, Nutlin -3 to reduce UVB-induced DNA damage melanocytes. The article published in the 2012 Volume 28 09 "Chinese Journal of Dermatology" on.
a-MSH pretreatment MC1R function normal human melanocytes, grouping be ultraviolet radiation (UVB, 105 mJ/cm2), Nutlin -3 (10μM) and UVB + Nutlin -3 different intervention methods, and using comet assay to determine the genomic DNA Tropsch tail ratio, tail moment and tail moment values.
UVB genomic DNA tail-rate, tail moment and tail moment values higher than the other groups (P <0.05), UVR + Nutlin -3 group was significantly lower than the UVB group (P <0.05).
Nutlin-3 against UV-induced human melanocytes protective effects of oxidative DNA damage
ReplyDeleteTan City, Jiangsu Province Hospital of Dermatology published a paper aimed at evaluating Nutlin -3 people against UV-induced oxidative DNA damage in melanocytes protective effect. Studies that, Nutlin -3 to reduce UVB-induced DNA damage melanocytes. The article published in the 2012 Volume 28 09 "Chinese Journal of Dermatology" on.
a-MSH pretreatment MC1R function normal human melanocytes, grouping be ultraviolet radiation (UVB, 105 mJ/cm2), Nutlin -3 (10μM) and UVB + Nutlin -3 different intervention methods, and using comet assay to determine the genomic DNA Tropsch tail ratio, tail moment and tail moment values.
UVB genomic DNA tail-rate, tail moment and tail moment values higher than the other groups (P <0.05), UVR + Nutlin -3 group was significantly lower than the UVB group (P <0.05).
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