BrCcnaBox
Let's market this device, we'll call it "bureaucracy-a-box", and it will basically be an ISO standard shipping container(izable) box with electrical hook ups and we'll stuff it with computers and network switches. We'll roll it out on flat bed truck in hati and it will act to restore governmental functionality (of a type and kind we program).
Rapid proliferation of tumor cells, and its frequent during mitosis and cell cycle was significantly shorter than normal cells. Microtubules during mitosis is important cytoskeleton, one of the dynamic instability of the structure, in the process of mitosis has prompted an important role in sister chromatid separation. This important role of the microtubules become an important target for anti-cancer therapy. Antimitotic drugs in cancer therapy plays an important role. They are primarily through the destruction of tubulin / microtubule dynamic loop between (polymerization and depolymerization) to treat a variety of solid tumors. Based on the role of different microtubule the drug into two categories: tubulin polymerization inhibiting drugs such as vinca alkaloids; stable microtubule drugs such as taxanes and epothilones classes. Tubulin polymerization inhibiting drugs with β tubulin binding to stop cell division in G_2 / M phase; stable microtubule drugs have two different binding sites: colchicine and vinblastine locus locus, but Similar mechanisms can reversibly binding to tubulin and β form "pharmaceutically - protein" complex to prevent monomers continue to add other proteins and inhibit tubulin polymerization, but also by inducing inhibition of microtubule depolymerization spindle formation, the cells in mitosis stopped at the M phase. Paclitaxel and docetaxel for the treatment of solid tumors is the first tubulin inhibitors, but due to the emergence of resistance, its application has been limited. In recent years, small molecule inhibitors of tubulin has made great progress. Among them, sulfa drugs, ABT-751 may be administered orally, bioavailability. It is with the colchicine binding site of β-tubulin binding, inhibition of tubulin polymerization, clinical studies are now being conducted. On the other hand, colchicine, podophyllotoxin, Combretastatin A-4 (CA-4) and other natural polyphenol molecule anticancer drugs ether structure tubulin polymerization of the main pharmacophore. Fragment based drug design (Fragment based drug design) is a recently developed, mature looking for an effective way to lead compounds.
ReplyDeleteMedchemexpress Can provide the above product,its website:www.medchemexpress.com
ABT-737
Nutlin-3a chiral
p53 and MDM2 proteins-interaction-inhibitor
Serdemetan
Nutlin-3b
Nutlin-3
p53 and MDM2 proteins-interaction-inhibitor chiral
p53 and MDM2 proteins-interaction-inhibitor (racemic)
YM-155
Pomalidomide