Protein acetylation pulmonary fibrosis and lung cancer
Protein lysine ε amino (Nε) acetylated peptide side chain amino group is acetylated, from lysine acetyltransferase (acetyltransferases, KATs) catalysis. This process is reversible, by deacetylation of histone deacetylase (histone deacetylases, HDACs) catalyzed finish. Nε acetylated (hereinafter referred to as K acetylation) is important in protein phosphorylation modification involved in various physiological and pathological processes. Protein acetylation in tumors, especially tumors of hematopoietic system has been extensive research, recently approved by the FDA HDACs inhibitors romidepsin (Istodax) and vorinostat (Zolinza) for the clinical treatment of cutaneous T-cell lymphoma. Protein acetylation with solid tumors and non-neoplastic diseases may become in the future relationship between the research hotspot, now protein acetylation in lung cancer and pulmonary fibrosis pathogenesis and treatment of lung cancer role as an overview.
Protein acetylation pulmonary fibrosis and lung cancer
ReplyDeleteProtein lysine ε amino (Nε) acetylated peptide side chain amino group is acetylated, from lysine acetyltransferase (acetyltransferases, KATs) catalysis. This process is reversible, by deacetylation of histone deacetylase (histone deacetylases, HDACs) catalyzed finish. Nε acetylated (hereinafter referred to as K acetylation) is important in protein phosphorylation modification involved in various physiological and pathological processes. Protein acetylation in tumors, especially tumors of hematopoietic system has been extensive research, recently approved by the FDA HDACs inhibitors romidepsin (Istodax) and vorinostat (Zolinza) for the clinical treatment of cutaneous T-cell lymphoma. Protein acetylation with solid tumors and non-neoplastic diseases may become in the future relationship between the research hotspot, now protein acetylation in lung cancer and pulmonary fibrosis pathogenesis and treatment of lung cancer role as an overview.
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