Tigecycline in vitro antibacterial activity against clinical strains
Abstract: Objective evaluation of tigecycline ( tetracycline antibiotic ) in vitro antibacterial activity against clinical strains . Methods broth dilution method for tigecycline and other 14 kinds of drugs for nearly two years in the hospital clinical specimens of 400 bacteria were isolated MIC determined by WHONET5.4 statistical software . The results showed that MIC determination : tigecycline against methicillin-resistant Staphylococcus aureus (MRSA) and Enterococcus showed good antibacterial activity in vitro test has three vancomycin-resistant enterococci (VRE), on behalf of tigecycline and linezolid -sensitive display ;Daptomycin， against Gram- negative bacteria Escherichia coli and ESBL-producing Klebsiella spp MIC ∞ are 1trg · mL ~, behind or below meropenem ; present study for tigecycline against Acinetobacter baumannii
The MIC. (2trg · mL a ) a minimum in all tests of antimicrobial drugs ; against Pseudomonas aeruginosa MIC ∞ value of 16p. g · mL ~.Tigecycline hydrochloride， Conclusion tigecycline against clinical pathogens have good broad-spectrum antimicrobial activity against Pseudomonas aeruginosa Yin poor antibacterial activity.
Tigecycline (tigecycline) is a derivative of minocycline , is the first clinical application of new glycyl doxycycline antibiotics . Intravenous drug formulations, in 2005 the U.S. Food and Drug Administration (FDA) approval : tigecycline for the treatment of patients aged 18 and older infections caused by susceptible strains , indications include : complicated intra-abdominal infections ( such as complicated appendicitis ,Tigecycline mesylate， burns infections, intra-abdominal abscesses, deep soft tissue infections and infected ulcers ) and complicated skin and soft tissue infections. The drug can overcome the limitations of many two main resistance mechanisms of antimicrobial drug use : efflux pumps and ribosomal protection. 1 shows a lot of old literature : the drug can be used to treat multi-drug resistant , such as MRSA, VRE, producing extended-spectrum 13 -lactamase bacterial infections caused by Enterobacteriaceae .Ofloxacin To understand the in vitro antibacterial activity of the drug , the trial of the 2009 and 2010 clinical isolates from the Ministry of Health, Beijing Hospital, 400 clinical MIC common bacteria were measured to evaluate the in vitro antibacterial activity of the drug .
Tigecycline in vitro antibacterial activity against clinical strains
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The MIC. (2trg · mL a ) a minimum in all tests of antimicrobial drugs ; against Pseudomonas aeruginosa MIC ∞ value of 16p. g · mL ~.Tigecycline hydrochloride， Conclusion tigecycline against clinical pathogens have good broad-spectrum antimicrobial activity against Pseudomonas aeruginosa Yin poor antibacterial activity.
Tigecycline (tigecycline) is a derivative of minocycline , is the first clinical application of new glycyl doxycycline antibiotics . Intravenous drug formulations, in 2005 the U.S. Food and Drug Administration (FDA) approval : tigecycline for the treatment of patients aged 18 and older infections caused by susceptible strains , indications include : complicated intra-abdominal infections ( such as complicated appendicitis ,Tigecycline mesylate， burns infections, intra-abdominal abscesses, deep soft tissue infections and infected ulcers ) and complicated skin and soft tissue infections. The drug can overcome the limitations of many two main resistance mechanisms of antimicrobial drug use : efflux pumps and ribosomal protection. 1 shows a lot of old literature : the drug can be used to treat multi-drug resistant , such as MRSA, VRE, producing extended-spectrum 13 -lactamase bacterial infections caused by Enterobacteriaceae .Ofloxacin
To understand the in vitro antibacterial activity of the drug , the trial of the 2009 and 2010 clinical isolates from the Ministry of Health, Beijing Hospital, 400 clinical MIC common bacteria were measured to evaluate the in vitro antibacterial activity of the drug .
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