Melatonin analogue agomelatine is effective in treating severe depression
Australian researchers found that melatonin analogues (Melatonin analogue) Agomelatine may be effective in treating severe depression. The research results on May 18 published in the British "Lancet" (The Lancet) magazine online edition. Melatonin analogues typically used to regulate human circadian rhythms and improve sleep, but it agomelatine has similar antidepressant commonly used antidepressant effect, and fewer side effects, better security. The researchers noted that traditional antidepressants can effectively alleviate the patient's depressive symptoms, but others seriously affect the quality of life symptoms such as sleep disorders, etc. can not be improved. Agomelatine same effect on 5-HT2c receptors, but a unique mode of action, for the treatment of severe depression and other mood disorders could play a significant role unique. The researchers compared the melatonin, ramelteon (ramelteon), U.S. Secretary Joan he (tasimelteon), PD-6735 and agomelatine found agomelatine in the treatment of severe depression, the most potential. In the short term effect, antidepressant effect of agomelatine and venlafaxine (venlafaxine), fluoxetine (Fluoxetine) and Zoloft (sertraline) is similar to the long term, taking agomelatine the relapse rate in patients with depression (23.9%) than for placebo (ratio of 50.0%) to be low. As agomelatine does not elevate the serum angiotensin-(5 - HT) levels, so its in the gastrointestinal tract, metabolism, and sexual side effects than other antidepressants less. Agomelatine on sale in Europe and Australia, but in the United States has not yet received FDA approval.
Melatonin analogue agomelatine is effective in treating severe depression
ReplyDeleteAustralian researchers found that melatonin analogues (Melatonin analogue) Agomelatine may be effective in treating severe depression. The research results on May 18 published in the British "Lancet" (The Lancet) magazine online edition.
Melatonin analogues typically used to regulate human circadian rhythms and improve sleep, but it agomelatine has similar antidepressant commonly used antidepressant effect, and fewer side effects, better security.
The researchers noted that traditional antidepressants can effectively alleviate the patient's depressive symptoms, but others seriously affect the quality of life symptoms such as sleep disorders, etc. can not be improved. Agomelatine same effect on 5-HT2c receptors, but a unique mode of action, for the treatment of severe depression and other mood disorders could play a significant role unique.
The researchers compared the melatonin, ramelteon (ramelteon), U.S. Secretary Joan he (tasimelteon), PD-6735 and agomelatine found agomelatine in the treatment of severe depression, the most potential.
In the short term effect, antidepressant effect of agomelatine and venlafaxine (venlafaxine), fluoxetine (Fluoxetine) and Zoloft (sertraline) is similar to the long term, taking agomelatine the relapse rate in patients with depression (23.9%) than for placebo (ratio of 50.0%) to be low.
As agomelatine does not elevate the serum angiotensin-(5 - HT) levels, so its in the gastrointestinal tract, metabolism, and sexual side effects than other antidepressants less.
Agomelatine on sale in Europe and Australia, but in the United States has not yet received FDA approval.
Medchemexpress Can provide the above product,its website:www.medchemexpress.com
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