COX 2 inhibitor combined with cisplatin or X-rays on A549 lung adenocarcinoma cell line in vitro
Observed cyclooxygenase 2 (COX 2) inhibitor celecoxib combined with chemotherapy drug cisplatin (DDP) or in combination with X-rays on A549 human lung adenocarcinoma cell proliferation and possible mechanisms. Methods MTS Celecoxib were detected with DDP combined with the impact of the proliferation of A549 cells and A549 cells combined with X-rays on survival fraction (SF) the impact of flow cytometry to detect apoptosis. Results in a certain concentration range, Celecoxib and DDP could inhibit A549 human lung adenocarcinoma cell growth, the inhibition was dose effect relationship. Both can be combined with enhanced growth inhibition of A549 cells, DDP concentration ≥ 1mg / L when the two have synergistic or additive effect. Celecoxib and X-rays combined with significantly reduced cell survival fraction (SF), increased apoptosis rate. Conclusions Celecoxib combined with DDP can enhance the A549 human lung adenocarcinoma cell growth inhibition; Celecoxib when combined with X-rays, can increase the A549 human lung adenocarcinoma cell apoptosis rate and enhance its sensitivity to radiation.
COX 2 inhibitor combined with cisplatin or X-rays on A549 lung adenocarcinoma cell line in vitro
ReplyDeleteObserved cyclooxygenase 2 (COX 2) inhibitor celecoxib combined with chemotherapy drug cisplatin (DDP) or in combination with X-rays on A549 human lung adenocarcinoma cell proliferation and possible mechanisms. Methods MTS Celecoxib were detected with DDP combined with the impact of the proliferation of A549 cells and A549 cells combined with X-rays on survival fraction (SF) the impact of flow cytometry to detect apoptosis. Results in a certain concentration range, Celecoxib and DDP could inhibit A549 human lung adenocarcinoma cell growth, the inhibition was dose effect relationship. Both can be combined with enhanced growth inhibition of A549 cells, DDP concentration ≥ 1mg / L when the two have synergistic or additive effect. Celecoxib and X-rays combined with significantly reduced cell survival fraction (SF), increased apoptosis rate. Conclusions Celecoxib combined with DDP can enhance the A549 human lung adenocarcinoma cell growth inhibition; Celecoxib when combined with X-rays, can increase the A549 human lung adenocarcinoma cell apoptosis rate and enhance its sensitivity to radiation.
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