Adenosine A_ (2A) receptor agonist CGS21680 analog of prostaglandin D_2 induced physiological sleep
Endogenous prostaglandin (Prostag (slightly), PG) D_2 can increase the basal forebrain adenosine levels under the subarachnoid space, may act on the adenosine A_ (2A) receptors, induce sleep. The experimental observation of adenosine A_ (2A) receptor agonist CGS21680 and PGD_2 similarities and differences between the role of promoting sleep. approach to the surgical insertion of stainless steel conduit under subarachnoid rat basal forebrain, and brain waves and muscle implants wave recording electrodes, after two Week (slightly) constant perfusion PGD_2 (200 pmol ? 0.2μl ~ (slightly) in ~ (-1)) or CGS21680 (10 pmol ? 0.2μl ~ (-1) ? min ~ (-1)), simultaneously recorded brain radio waves and muscle, analyze the amount of sleep, sleep intensity and sleep phase conversion parameters were compared with artificial cerebrospinal fluid self-control, PGD_2 and CGS21680 were significantly increased slow wave sleep (non-rapid eye movement (slightly) sleep intensity, both in the phase transformation and the time course of each band showed a high degree of similarity. CGS21680 to increase the amount of REM sleep, while PGD_2 not cause the amount of REM sleep increases. conclusions adenosine A_ (2A) receptor agonist CGS21680 can analog PGD_2 induced slow-wave sleep, suggesting that adenosine A_ (2A) receptor induces physiological sleep is one of the important targets.
Adenosine A_ (2A) receptor agonist CGS21680 analog of prostaglandin D_2 induced physiological sleep
ReplyDeleteEndogenous prostaglandin (Prostag (slightly), PG) D_2 can increase the basal forebrain adenosine levels under the subarachnoid space, may act on the adenosine A_ (2A) receptors, induce sleep. The experimental observation of adenosine A_ (2A) receptor agonist CGS21680 and PGD_2 similarities and differences between the role of promoting sleep. approach to the surgical insertion of stainless steel conduit under subarachnoid rat basal forebrain, and brain waves and muscle implants wave recording electrodes, after two Week (slightly) constant perfusion PGD_2 (200 pmol ? 0.2μl ~ (slightly) in ~ (-1)) or CGS21680 (10 pmol ? 0.2μl ~ (-1) ? min ~ (-1)), simultaneously recorded brain radio waves and muscle, analyze the amount of sleep, sleep intensity and sleep phase conversion parameters were compared with artificial cerebrospinal fluid self-control, PGD_2 and CGS21680 were significantly increased slow wave sleep (non-rapid eye movement (slightly) sleep intensity, both in the phase transformation and the time course of each band showed a high degree of similarity. CGS21680 to increase the amount of REM sleep, while PGD_2 not cause the amount of REM sleep increases. conclusions adenosine A_ (2A) receptor agonist CGS21680 can analog PGD_2 induced slow-wave sleep, suggesting that adenosine A_ (2A) receptor induces physiological sleep is one of the important targets.
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